Hope Lab, Hope Laboratory, Kristin Hope

Select Publications

Rentas S, Holzapfel N, Belew M, Pratt G, Voisin V, Bader G, Wilhelm B, Yeo G, Hope KJ. Musashi2 Attenuates AHR Signaling to Expand Human Hematopoietic Stem Cells. In press, Nature, March 2016. [FULL ARTICLE]


Ivetic N, Nazi I, Karim N, Clare R, Smith JW, Moore JC, Hope KJ, Kelton JG, Arnold DM. (2016). Producing megakaryocytes from a human peripheral blood source. Transfusion. doi: 10.1111/trf.13461. [Epub ahead of print] [FULL ARTICLE]


Cellot S, Hope KJ, Sauvageau M, Chagraoui J, Deneault E, MacRae T, Mayotte TN, Wilhelm BT, Landry JR, Ting SB, Krosl J, Thompson A, Humphries K and Sauvageau G. (2013). RNAi screen identifies Jarid1b as a major regulator of mouse HSC self-renewal. Blood. 122(9):1545-55. [FULL ARTICLE]


Rentas S, Holzapfel N and Hope KJ. (2013). Cancer Stem Cells: Prospective Isolation and Progress Toward

Functional Biomarker Identification. Curr Pathobiol Reports. 1(2):81-90. [FULL ARTICLE]


Hereault O*, Hope KJ*, Deneault E, Mayotte N, Chagraoui J, Whilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, and Sauvageau G*. (2012). A role for GPx3 in activity of normal and leukemia stem cells. Journal of Experimental Medicine. 209(5):895-901. *authors made equal contribution. [FULL ARTICLE]

Ting SB, Deneault E, Hope KJ, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G. (2012). Asymmetrical segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. Blood. 119(11):2510-22. [FULL ARTICLE]


Hope KJ* and Sauvageau G*. (2011). Roles for MSI2 and PROX1 in hematopoietic stem cell activity. Curr Opin Hematol. 18(4):203-207. *authors made equal contribution. [FULL ARTICLE]


Hope KJ* and Bhatia M*. (2011). Clonal interrogation of stem cells. Nature Methods. 8(4 Suppl):S36-40. *authors made equal contribution. [FULL ARTICLE]


Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope KJ, Girard S, Mayotte N, Landry JR, H├ębert J, Sauvageau G. (2011). RNA-seq of two closely related leukemia clones that differ in their self-renewal capacity. Blood. 117(2):e27-38. [FULL ARTICLE]


Hope KJ, Cellot S, Ting S, MacRae T, Mayotte N, Iscove NN, Sauvageau G. (2010). An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell. 7(1):101-113. [FULL ARTICLE]

Dr. Kristin Hope  |  Assistant Professor, Department of Biochemistry and Biomedical Sciences  |  Scientist, McMaster Stem Cell and Cancer Research Institute

Michael G. DeGroote Centre for Learning and Discovery, Room 5025  |  McMaster University  |  1280 Main Street West  |  Hamilton, Ontario L8S4L8